It participates in the complement cascade ending with cell death.
2.
Inhibition of the complement cascade can decrease this damage.
3.
Serum sickness is primarily caused by the antibodies clumping during infusion and triggering the complement cascade.
4.
These antibodies bind to antigens, making them easier targets for phagocytes, and trigger the complement cascade.
5.
LTA bound to targets can interact with circulating antibodies and activate the complement cascade to induce a passive immune kill phenomenon.
6.
The anaphylatoxins C3a, C4a, and C5a are cationic fragments generated during the complement cascade that participate in host defense.
7.
Eculizumab is a recombinant humanized monoclonal IgG2 / 4 antibody that selectively targets and inhibits the terminal portion of the complement cascade.
8.
Eculizumab specifically binds to the terminal Complement component 5, or C5, which acts at a late stage in the complement cascade.
9.
Activation of the complement cascade attracts phagocytes that leak peroxide and other reagents, which may increase the damage for the surviving heart cells.
10.
There are four different C5 convertases able to specifically convert alternative pathway ( "'C3bBbC3b "') of complement cascade.
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